OncoDB.HCC Expression View

Gene name : MMP12
Ensembl ID ENSG00000110347
Description Macrophage metalloelastase precursor (EC 3.4.24.65) (HME) (Matrix metalloproteinase-12) (MMP-12) (Macrophage elastase) (ME). [Source:Uniprot/SWISSPROT;Acc:P39900]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
50 percent with 2 folds change ( 14 up and 3 down in 34 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- Northern    
>> Link to terminologies used in OncoDB.HCC
Links Entrez Gene    
Display nearby genome region Chr 11 from 97238686 bp to 107250922 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 196612 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (1.19) HK3 (2.30) HK4 (-1.38) HK5 (0.00) HK7 (0.00) HK9 (0.00) HK11 (0.00) HK12 (-0.82) HK13 (-0.40) HK14 (3.11) HK15 (0.96) HK16 (2.35) HK18 (1.89) HK19 (1.48) HK20 (0.00) HK21 (0.03) HK22 (-0.41) HK24 (3.03) HK27 (5.10) HK28 (-0.55) HK29 (-0.08) HK31 (0.00) HK33 (0.00) HK36 (1.47) HK37 (-0.02) HK38 (0.84) HK39 (3.30) HK42 (0.00) HK46 (0.08) HK47 (1.52) HK49 (0.20) HK62 (0.00) HK63 (0.00) HK64 (-1.19) HK67 (0.00) HK84 (0.00) HK85 (0.00) SF1 (0.00) SF12 (0.00) SF15 (0.00) SF17 (0.00) SF18 (0.00) SF21 (0.00) SF22 (0.00) SF23 (0.00) SF32 (-1.14) SF34 (-0.00) SF35 (0.19) SF3 (1.13) SF30 (1.09) HK2 (0.00) HK23 (0.71) HK41 (-0.24) SF4 (0.49) SF8 (-0.29) SF9 (5.35)