OncoDB.HCC Expression View

Gene name : CD81
Ensembl ID ENSG00000110651
Description CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (Tetraspanin-28) (Tspan-28). [Source:Uniprot/SWISSPROT;Acc:P60033]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
40 percent with 2 folds change ( 1 up and 22 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- IHC, RT-PCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     cDNA Microarray - - Iizuka et al., Oncogene 22:3007 (2003)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 11 from 0 bp to 7375225 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 840978 -- IMAGE clone locate on exon ( tblastx )
CH2 (-1.74) HK1 (-0.76) HK3 (-1.10) HK4 (-1.42) HK5 (-0.05) HK7 (0.32) HK9 (-1.07) HK11 (0.56) HK12 (-1.13) HK13 (-0.70) HK14 (-1.65) HK15 (-0.13) HK16 (1.09) HK18 (-0.72) HK19 (-0.70) HK20 (-2.39) HK21 (-0.30) HK22 (-0.62) HK24 (-1.65) HK27 (-0.28) HK28 (-0.25) HK29 (-0.42) HK31 (-0.67) HK33 (-0.70) HK36 (-0.89) HK37 (-0.60) HK38 (-0.79) HK39 (-0.37) HK42 (-1.75) HK46 (-0.83) HK47 (-1.56) HK49 (-0.84) HK62 (0.39) HK63 (-1.85) HK64 (-2.50) HK67 (-1.87) HK84 (-1.17) HK85 (-2.98) SF1 (-0.64) SF12 (-2.42) SF15 (-2.09) SF17 (0.23) SF18 (-0.14) SF21 (0.01) SF22 (-0.98) SF23 (-1.19) SF32 (0.15) SF34 (-0.33) SF35 (-0.53) SF3 (-1.29) SF30 (-0.29) HK2 (-1.81) HK23 (-0.58) HK41 (-1.82) SF4 (-0.57) SF8 (-0.31) SF9 (-1.62)