OncoDB.HCC Expression View

Gene name : CAP2
Ensembl ID ENSG00000112186
Description Adenylyl cyclase-associated protein 2 (CAP 2). [Source:Uniprot/SWISSPROT;Acc:P40123]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
69 percent with 2 folds change ( 37 up and 0 down in 53 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- QPCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 6 from 12501715 bp to 22666000 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 487297 -- IMAGE clone locate on exon ( tblastx )
CH2 (2.67) HK1 (2.57) HK3 (0.87) HK4 (2.67) HK5 (0.00) HK7 (0.02) HK9 (0.09) HK11 (1.56) HK12 (0.87) HK13 (1.65) HK14 (2.10) HK15 (3.44) HK16 (0.27) HK18 (2.58) HK19 (0.67) HK20 (0.85) HK21 (0.54) HK22 (0.43) HK24 (3.52) HK27 (4.75) HK28 (2.15) HK29 (2.71) HK31 (1.93) HK33 (3.27) HK36 (1.61) HK37 (0.00) HK38 (1.96) HK39 (0.27) HK42 (1.17) HK46 (2.10) HK47 (2.40) HK49 (1.04) HK62 (-0.68) HK63 (1.72) HK64 (1.47) HK67 (1.19) HK84 (0.00) HK85 (1.08) SF1 (0.89) SF12 (1.53) SF15 (0.00) SF17 (2.05) SF18 (4.03) SF21 (0.58) SF22 (1.73) SF23 (0.24) SF32 (1.18) SF34 (0.89) SF35 (1.39) SF3 (2.62) SF30 (1.09) HK2 (2.34) HK23 (3.06) HK41 (2.63) SF4 (0.96) SF8 (2.76) SF9 (1.11)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).