OncoDB.HCC Expression View

Gene name : GMNN
Ensembl ID ENSG00000112312
Description Geminin. [Source:Uniprot/SWISSPROT;Acc:O75496]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
76 percent with 2 folds change ( 43 up and 0 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
up     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
up     Oligo Microarray - - Tackels-Horne et al., Cancer 92:395 (2001)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 6 from 19883138 bp to 29894306 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 813586 -- IMAGE clone locate on exon ( tblastx )
CH2 (2.90) HK1 (1.04) HK3 (3.19) HK4 (1.81) HK5 (0.98) HK7 (-0.01) HK9 (2.20) HK11 (2.21) HK12 (1.69) HK13 (3.31) HK14 (2.56) HK15 (1.29) HK16 (0.53) HK18 (1.07) HK19 (1.39) HK20 (2.37) HK21 (2.01) HK22 (2.33) HK24 (1.66) HK27 (1.47) HK28 (1.61) HK29 (0.00) HK31 (1.19) HK33 (2.52) HK36 (0.69) HK37 (1.74) HK38 (3.65) HK39 (0.69) HK42 (3.78) HK46 (1.01) HK47 (2.03) HK49 (1.58) HK62 (0.42) HK63 (1.90) HK64 (0.77) HK67 (2.75) HK84 (1.37) HK85 (2.46) SF1 (2.61) SF12 (2.06) SF15 (1.04) SF17 (-0.10) SF18 (0.71) SF21 (-0.78) SF22 (2.32) SF23 (-0.64) SF32 (0.98) SF34 (2.84) SF35 (2.97) SF3 (1.37) SF30 (1.74) HK2 (0.60) HK23 (2.78) HK41 (2.51) SF4 (1.01) SF8 (1.47) SF9 (1.90)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).