OncoDB.HCC Expression View

Gene name : GHR
Ensembl ID ENSG00000112964
Description Growth hormone receptor precursor (GH receptor) (Somatotropin receptor) [Contains: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]. [Source:Uniprot/SWISSPROT;Acc:P10912]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
75 percent with 2 folds change ( 7 up and 34 down in 54 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 5 from 37459783 bp to 47757736 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 295389 -- IMAGE clone locate on exon ( tblastx )
378565 -- IMAGE clone locate on exon ( tblastx )
CH2 (-2.07) HK1 (-1.96) HK3 (-2.68) HK4 (-3.36) HK5 (-2.26) HK7 (-0.69) HK9 (-0.69) HK11 (-0.70) HK12 (-0.60) HK13 (-0.57) HK14 (-5.28) HK15 (-5.19) HK16 (-1.55) HK18 (-2.47) HK19 (-0.10) HK20 (-1.71) HK21 (-2.41) HK22 (0.75) HK24 (-0.36) HK27 (-3.49) HK28 (-1.28) HK29 (-1.48) HK31 (1.04) HK33 (2.28) HK36 (-2.03) HK37 (-6.01) HK38 (-1.38) HK39 (-1.73) HK42 (1.37) HK46 (-5.69) HK47 (-6.36) HK49 (-1.04) HK62 (0.00) HK63 (-0.46) HK64 (-1.60) HK67 (0.00) HK84 (-4.78) HK85 (1.29) SF1 (-4.10) SF12 (-5.43) SF15 (-2.62) SF17 (1.36) SF18 (0.95) SF21 (3.19) SF22 (0.00) SF23 (0.11) SF32 (2.41) SF34 (-1.59) SF35 (-2.66) SF3 (-1.52) SF30 (-2.40) HK2 (-1.92) HK23 (-1.90) HK41 (-3.33) SF4 (0.57) SF8 (0.08) SF9 (-6.55)