OncoDB.HCC Expression View

Gene name : SPARC
Ensembl ID ENSG00000113140
Description SPARC precursor (Secreted protein acidic and rich in cysteine) (Osteonectin) (ON) (Basement-membrane protein 40) (BM-40). [Source:Uniprot/SWISSPROT;Acc:P09486]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
52 percent with 2 folds change ( 25 up and 1 down in 50 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- IHC, ISH    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     cDNA Microarray - - Delpuech et al., Oncogene 21:2926 (2002)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 5 from 146021212 bp to 156046710 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 293917 -- IMAGE clone locate on exon ( tblastx )
487878 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.32) HK1 (1.47) HK3 (2.13) HK4 (0.09) HK5 (1.00) HK7 (1.14) HK9 (0.58) HK11 (2.53) HK12 (1.07) HK13 (1.24) HK14 (0.38) HK15 (1.68) HK16 (1.02) HK18 (0.26) HK19 (1.34) HK20 (0.12) HK21 (2.54) HK22 (1.39) HK24 (1.86) HK27 (2.86) HK28 (-0.13) HK29 (0.43) HK31 (2.14) HK33 (0.70) HK36 (1.21) HK37 (1.02) HK38 (1.85) HK39 (1.86) HK42 (0.36) HK46 (0.00) HK47 (0.00) HK49 (0.00) HK62 (1.78) HK63 (-1.53) HK64 (0.38) HK67 (-0.34) HK84 (-0.17) HK85 (-0.10) SF1 (1.00) SF12 (0.54) SF15 (0.78) SF17 (0.21) SF18 (1.42) SF21 (0.58) SF22 (1.74) SF23 (-0.80) SF32 (0.57) SF34 (1.01) SF35 (2.92) SF3 (0.25) SF30 (0.47) HK2 (-0.03) HK23 (0.00) HK41 (1.43) SF4 (0.00) SF8 (0.00) SF9 (0.00)