OncoDB.HCC Expression View

Gene name : SMC4
Ensembl ID ENSG00000113810
Description Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog). [Source:Uniprot/SWISSPROT;Acc:Q9NTJ3]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
42 percent with 2 folds change ( 24 up and 0 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
up     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene     COSMIC    
Display nearby genome region Chr 3 from 156600124 bp to 166635433 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 786504 -- IMAGE clone locate on exon ( tblastx )
CH2 (1.23) HK1 (0.64) HK3 (1.48) HK4 (0.93) HK5 (0.04) HK7 (1.08) HK9 (10.00) HK11 (0.89) HK12 (0.45) HK13 (1.17) HK14 (1.58) HK15 (-0.01) HK16 (0.62) HK18 (0.74) HK19 (0.84) HK20 (1.01) HK21 (1.14) HK22 (0.39) HK24 (0.80) HK27 (1.13) HK28 (-0.23) HK29 (0.47) HK31 (-0.14) HK33 (0.65) HK36 (1.65) HK37 (1.54) HK38 (1.46) HK39 (1.29) HK42 (1.68) HK46 (1.20) HK47 (1.08) HK49 (1.19) HK62 (1.07) HK63 (1.44) HK64 (0.29) HK67 (0.32) HK84 (0.46) HK85 (1.86) SF1 (0.28) SF12 (1.03) SF15 (-0.34) SF17 (-0.24) SF18 (0.86) SF21 (0.00) SF22 (1.06) SF23 (-0.26) SF32 (0.04) SF34 (0.24) SF35 (1.08) SF3 (0.43) SF30 (2.03) HK2 (-0.38) HK23 (-0.00) HK41 (0.49) SF4 (0.71) SF8 (0.33) SF9 (0.63)