OncoDB.HCC Expression View

Gene name : VIPR1
Ensembl ID ENSG00000114812
Description Vasoactive intestinal polypeptide receptor 1 precursor (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2). [Source:Uniprot/SWISSPROT;Acc:P32241]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
91 percent with 2 folds change ( 0 up and 41 down in 45 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 3 from 37519121 bp to 47554064 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 215000 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (-3.81) HK3 (-2.95) HK4 (0.00) HK5 (0.00) HK7 (-4.31) HK9 (0.00) HK11 (-3.45) HK12 (-2.90) HK13 (-1.88) HK14 (-3.71) HK15 (-2.19) HK16 (-1.98) HK18 (-2.94) HK19 (-2.43) HK20 (0.00) HK21 (-3.28) HK22 (-0.94) HK24 (-3.67) HK27 (-3.40) HK28 (-0.17) HK29 (-1.44) HK31 (-3.02) HK33 (-7.04) HK36 (-1.88) HK37 (-4.94) HK38 (-3.34) HK39 (-3.09) HK42 (-3.63) HK46 (-4.88) HK47 (-9.85) HK49 (-4.49) HK62 (-0.67) HK63 (0.00) HK64 (-3.91) HK67 (0.00) HK84 (0.00) HK85 (-4.88) SF1 (0.00) SF12 (-4.10) SF15 (-4.64) SF17 (0.00) SF18 (0.00) SF21 (-0.52) SF22 (-3.42) SF23 (-3.50) SF32 (-3.19) SF34 (-2.24) SF35 (-2.85) SF3 (-4.87) SF30 (0.00) HK2 (-4.76) HK23 (-3.69) HK41 (-4.81) SF4 (-2.88) SF8 (-2.72) SF9 (-4.93)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).