OncoDB.HCC Expression View

Gene name : LEPR
Ensembl ID ENSG00000116678
Description Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (HuB219) (CD295 antigen). [Source:Uniprot/SWISSPROT;Acc:P48357]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
48 percent with 2 folds change ( 1 up and 25 down in 54 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up/down     Method -- IHC    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene     Entrez Gene     Entrez Gene     Entrez Gene     Entrez Gene    
Display nearby genome region Chr 1 from 60658858 bp to 70879830 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 154428 -- IMAGE clone locate on exon ( blastn )
154996 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (-0.69) HK3 (-0.49) HK4 (-2.14) HK5 (-0.45) HK7 (0.39) HK9 (-0.77) HK11 (-2.68) HK12 (0.24) HK13 (0.13) HK14 (-2.60) HK15 (-2.99) HK16 (0.00) HK18 (-0.29) HK19 (-1.23) HK20 (0.42) HK21 (-1.88) HK22 (-0.23) HK24 (-0.49) HK27 (-1.29) HK28 (-0.09) HK29 (0.17) HK31 (-0.08) HK33 (2.41) HK36 (-0.66) HK37 (-1.51) HK38 (-2.45) HK39 (-1.19) HK42 (-1.96) HK46 (-0.75) HK47 (0.00) HK49 (-1.33) HK62 (-1.13) HK63 (-0.81) HK64 (-0.91) HK67 (-0.46) HK84 (-1.14) HK85 (-0.70) SF1 (-2.04) SF12 (-2.20) SF15 (-2.06) SF17 (0.83) SF18 (-1.81) SF21 (-0.24) SF22 (-2.85) SF23 (0.49) SF32 (-0.41) SF34 (-1.26) SF35 (-1.60) SF3 (-1.28) SF30 (-2.01) HK2 (-0.56) HK23 (0.49) HK41 (0.61) SF4 (-2.22) SF8 (-0.85) SF9 (-2.79)