OncoDB.HCC Expression View

Gene name : MTR
Ensembl ID ENSG00000116984
Description Methionine synthase (EC 2.1.1.13) (5-methyltetrahydrofolate-- homocysteine methyltransferase) (Methionine synthase, vitamin-B12 dependent) (MS). [Source:Uniprot/SWISSPROT;Acc:Q99707]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
35 percent with 2 folds change ( 14 up and 0 down in 40 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- RT-PCR    
>> Link to terminologies used in OncoDB.HCC
Links Entrez Gene    
Display nearby genome region Chr 1 from 230025233 bp to 240133904 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 666169 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (1.11) HK3 (1.50) HK4 (-0.49) HK5 (0.93) HK7 (0.00) HK9 (0.00) HK11 (-0.24) HK12 (0.27) HK13 (-0.09) HK14 (-0.16) HK15 (0.35) HK16 (-0.04) HK18 (0.67) HK19 (0.54) HK20 (-0.24) HK21 (1.37) HK22 (0.79) HK24 (1.01) HK27 (1.43) HK28 (0.37) HK29 (0.00) HK31 (-0.39) HK33 (1.15) HK36 (0.00) HK37 (0.00) HK38 (1.63) HK39 (1.80) HK42 (1.11) HK46 (-0.04) HK47 (1.82) HK49 (1.37) HK62 (0.41) HK63 (0.00) HK64 (-0.22) HK67 (0.00) HK84 (0.76) HK85 (-0.06) SF1 (0.00) SF12 (0.00) SF15 (0.00) SF17 (0.00) SF18 (0.00) SF21 (0.00) SF22 (0.79) SF23 (-0.72) SF32 (1.60) SF34 (1.94) SF35 (0.00) SF3 (0.00) SF30 (0.00) HK2 (0.24) HK23 (0.13) HK41 (0.76) SF4 (1.22) SF8 (0.35) SF9 (0.97)