OncoDB.HCC Expression View

Gene name : CDC20
Ensembl ID ENSG00000117399
Description Cell division cycle protein 20 homolog (p55CDC). [Source:Uniprot/SWISSPROT;Acc:Q12834]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
74 percent with 2 folds change ( 28 up and 12 down in 54 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
up     cDNA Microarray - - Honda et al., Gastroenterology 120:955(2001)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene     Entrez Gene     COSMIC    
Display nearby genome region Chr 1 from 38597199 bp to 48601461 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 898062 -- IMAGE clone locate on exon ( tblastx )
CH2 (-6.26) HK1 (9.87) HK3 (2.96) HK4 (2.63) HK5 (0.75) HK7 (2.51) HK9 (3.35) HK11 (1.25) HK12 (0.19) HK13 (3.28) HK14 (3.76) HK15 (1.39) HK16 (5.69) HK18 (4.22) HK19 (1.95) HK20 (0.03) HK21 (1.95) HK22 (-8.17) HK24 (2.33) HK27 (5.88) HK28 (-0.47) HK29 (3.69) HK31 (0.61) HK33 (1.45) HK36 (-9.34) HK37 (2.67) HK38 (1.16) HK39 (3.96) HK42 (2.21) HK46 (0.00) HK47 (0.00) HK49 (0.00) HK62 (0.27) HK63 (2.94) HK64 (0.00) HK67 (-0.27) HK84 (2.90) HK85 (-4.90) SF1 (-7.78) SF12 (0.00) SF15 (-2.08) SF17 (4.31) SF18 (-5.03) SF21 (-7.01) SF22 (-5.79) SF23 (-0.79) SF32 (1.06) SF34 (7.71) SF35 (-5.22) SF3 (-7.58) SF30 (4.80) HK2 (-1.82) HK23 (0.36) HK41 (0.91) SF4 (0.74) SF8 (0.67) SF9 (1.55)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).