OncoDB.HCC Expression View

Gene name : PRDX1
Ensembl ID ENSG00000117450
Description Peroxiredoxin-1 (EC 1.11.1.15) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Proliferation-associated gene protein) (PAG) (Natural killer cell-enhancing factor A) (NKEF-A). [Source:Uniprot/SWISSPROT;Acc:Q06830]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
47 percent with 2 folds change ( 24 up and 1 down in 53 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
down     Proteomic Analysis - - Li et al., Mol Cell Proteomics 3:399 (2004)
down     Proteomic Analysis - - Blanc et al., Proteomics 5:37788 (2005)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 1 from 40749295 bp to 50760215 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 878259 -- IMAGE clone locate on exon ( blastn )
CH2 (0.22) HK1 (0.69) HK3 (1.60) HK4 (2.78) HK5 (0.19) HK7 (0.86) HK9 (-0.07) HK11 (1.29) HK12 (0.39) HK13 (2.13) HK14 (1.17) HK15 (1.47) HK16 (0.77) HK18 (1.55) HK19 (-0.15) HK20 (0.83) HK21 (0.07) HK22 (0.61) HK24 (1.07) HK27 (1.02) HK28 (0.96) HK29 (0.84) HK31 (1.04) HK33 (0.86) HK36 (-0.14) HK37 (2.28) HK38 (0.52) HK39 (1.48) HK42 (1.88) HK46 (0.00) HK47 (1.49) HK49 (0.03) HK62 (-1.68) HK63 (1.15) HK64 (0.80) HK67 (0.19) HK84 (3.18) HK85 (-0.80) SF1 (1.51) SF12 (2.14) SF15 (0.50) SF17 (0.05) SF18 (0.00) SF21 (-0.49) SF22 (0.00) SF23 (0.00) SF32 (1.16) SF34 (1.85) SF35 (1.76) SF3 (0.80) SF30 (1.07) HK2 (-0.04) HK23 (0.18) HK41 (1.23) SF4 (0.87) SF8 (0.40) SF9 (1.55)