OncoDB.HCC Expression View

Gene name : STMN1
Ensembl ID ENSG00000117632
Description Stathmin (Phosphoprotein p19) (pp19) (Oncoprotein 18) (Op18) (Leukemia-associated phosphoprotein p18) (pp17) (Prosolin) (Metablastin) (Protein Pr22). [Source:Uniprot/SWISSPROT;Acc:P16949]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
82 percent with 2 folds change ( 39 up and 7 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- RT-PCR, QPCR, IHC, Western    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
up     Oligo Microarray - - Tackels-Horne et al., Cancer 92:395 (2001)
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
up     Proteomic Analysis - - Li et al., Proteomics 5:1125 (2005)
Links Entrez Gene     Entrez Gene     Entrez Gene    
Display nearby genome region Chr 1 from 21099180 bp to 31105955 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 1476065 -- IMAGE clone locate on exon ( tblastx )
CH2 (2.94) HK1 (5.53) HK3 (1.68) HK4 (2.02) HK5 (0.80) HK7 (2.48) HK9 (3.62) HK11 (2.84) HK12 (-0.13) HK13 (3.52) HK14 (4.86) HK15 (1.82) HK16 (1.30) HK18 (2.16) HK19 (4.12) HK20 (3.14) HK21 (2.53) HK22 (1.54) HK24 (5.96) HK27 (3.63) HK28 (-9.59) HK29 (5.20) HK31 (0.71) HK33 (2.07) HK36 (-9.06) HK37 (0.00) HK38 (4.05) HK39 (2.74) HK42 (4.44) HK46 (1.87) HK47 (3.66) HK49 (1.58) HK62 (3.03) HK63 (3.20) HK64 (1.92) HK67 (1.04) HK84 (4.12) HK85 (-6.19) SF1 (3.12) SF12 (3.16) SF15 (0.50) SF17 (-0.45) SF18 (-0.12) SF21 (3.16) SF22 (2.07) SF23 (0.64) SF32 (0.16) SF34 (-7.80) SF35 (-5.92) SF3 (-9.49) SF30 (4.43) HK2 (0.13) HK23 (-2.47) HK41 (3.14) SF4 (0.35) SF8 (1.14) SF9 (5.68)