OncoDB.HCC Expression View

Gene name : ARG1
Ensembl ID ENSG00000118520
Description Arginase-1 (EC 3.5.3.1) (Type I arginase) (Liver-type arginase). [Source:Uniprot/SWISSPROT;Acc:P05089]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
62 percent with 2 folds change ( 9 up and 24 down in 53 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- Western    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
down     Proteomic Analysis - - Kim et al., Clin Cancer Research 9:5493 (2003)
down     Proteomic Analysis - - Yokoyama et al., Proteomics 4:21111 (2004)
down     Proteomic Analysis - - Liang et al., Proteomics 5:2258 (2005)
Links Entrez Gene    
Display nearby genome region Chr 6 from 126935977 bp to 136947165 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 813635 -- IMAGE clone locate on exon ( tblastx )
CH2 (-1.14) HK1 (-3.18) HK3 (-0.97) HK4 (-5.66) HK5 (0.00) HK7 (-1.57) HK9 (1.41) HK11 (-0.54) HK12 (-0.34) HK13 (-1.23) HK14 (-2.54) HK15 (-1.76) HK16 (-1.53) HK18 (-0.55) HK19 (0.00) HK20 (-0.92) HK21 (-1.47) HK22 (0.73) HK24 (-0.15) HK27 (-2.61) HK28 (-2.85) HK29 (-0.87) HK31 (0.71) HK33 (0.54) HK36 (-2.64) HK37 (-2.47) HK38 (-1.64) HK39 (-2.41) HK42 (-2.69) HK46 (0.96) HK47 (-2.20) HK49 (3.30) HK62 (1.11) HK63 (0.52) HK64 (-1.79) HK67 (2.11) HK84 (-3.68) HK85 (1.13) SF1 (-0.98) SF12 (-1.10) SF15 (-3.07) SF17 (1.48) SF18 (-0.26) SF21 (0.56) SF22 (5.10) SF23 (-1.57) SF32 (3.27) SF34 (0.00) SF35 (0.00) SF3 (-0.89) SF30 (-3.61) HK2 (1.30) HK23 (-0.65) HK41 (0.97) SF4 (-0.19) SF8 (0.34) SF9 (-3.28)