OncoDB.HCC Expression View

Gene name : ABCG2
Ensembl ID ENSG00000118777
Description ATP-binding cassette sub-family G member 2 (Placenta-specific ATP- binding cassette transporter) (Breast cancer resistance protein) (Mitoxantrone resistance-associated protein) (CD338 antigen) (CDw338). [Source:Uniprot/SWISSPROT;Acc:Q9UNQ0]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
12 percent with 2 folds change ( 1 up and 6 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- QPCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
Links Entrez Gene    
Display nearby genome region Chr 4 from 84230441 bp to 94299035 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 32110 -- IMAGE clone locate on exon ( tblastx )
288736 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.87) HK1 (0.46) HK3 (-0.67) HK4 (-1.05) HK5 (-0.33) HK7 (0.31) HK9 (-1.19) HK11 (-0.97) HK12 (-0.28) HK13 (-0.79) HK14 (-0.39) HK15 (-0.95) HK16 (0.19) HK18 (-0.13) HK19 (-0.12) HK20 (-0.72) HK21 (-1.31) HK22 (-0.12) HK24 (-0.30) HK27 (-0.64) HK28 (-0.18) HK29 (0.20) HK31 (0.46) HK33 (0.60) HK36 (-0.23) HK37 (-0.39) HK38 (-0.08) HK39 (0.07) HK42 (0.75) HK46 (-0.50) HK47 (-0.84) HK49 (-1.30) HK62 (0.19) HK63 (0.50) HK64 (-0.39) HK67 (-0.50) HK84 (-0.26) HK85 (-0.60) SF1 (-0.94) SF12 (-0.93) SF15 (-0.12) SF17 (1.76) SF18 (0.04) SF21 (0.78) SF22 (0.00) SF23 (-0.67) SF32 (0.51) SF34 (0.66) SF35 (-0.94) SF3 (-0.88) SF30 (-1.30) HK2 (-0.18) HK23 (0.07) HK41 (-0.11) SF4 (0.39) SF8 (-0.69) SF9 (-1.75)