OncoDB.HCC Expression View

Gene name : SPP1
Ensembl ID ENSG00000118785
Description Osteopontin precursor (Bone sialoprotein-1) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Nephropontin) (Uropontin). [Source:Uniprot/SWISSPROT;Acc:P10451]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
78 percent with 2 folds change ( 31 up and 12 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- RT-PCR, IHC    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 4 from 84115890 bp to 94123592 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 378461 -- IMAGE clone locate on exon ( tblastx )
CH2 (-1.96) HK1 (4.27) HK3 (7.21) HK4 (-0.77) HK5 (5.95) HK7 (1.45) HK9 (0.00) HK11 (0.79) HK12 (-2.68) HK13 (-2.62) HK14 (3.72) HK15 (4.29) HK16 (3.67) HK18 (3.57) HK19 (0.34) HK20 (0.90) HK21 (4.61) HK22 (0.07) HK24 (6.07) HK27 (6.99) HK28 (-1.81) HK29 (-2.14) HK31 (0.18) HK33 (1.25) HK36 (-0.51) HK37 (3.88) HK38 (2.49) HK39 (4.56) HK42 (-0.32) HK46 (1.24) HK47 (4.92) HK49 (0.00) HK62 (1.77) HK63 (-1.18) HK64 (2.44) HK67 (-2.80) HK84 (1.41) HK85 (-1.99) SF1 (4.36) SF12 (4.42) SF15 (-0.90) SF17 (-1.94) SF18 (5.58) SF21 (0.10) SF22 (7.35) SF23 (-3.46) SF32 (-0.56) SF34 (-3.30) SF35 (8.17) SF3 (2.92) SF30 (1.49) HK2 (-1.01) HK23 (6.64) HK41 (6.87) SF4 (0.64) SF8 (5.86) SF9 (3.54)