OncoDB.HCC Expression View

Gene name : DNMT3A
Ensembl ID ENSG00000119772
Description DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA). [Source:Uniprot/SWISSPROT;Acc:Q9Y6K1]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
35 percent with 2 folds change ( 17 up and 1 down in 51 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- RT-PCR, IHC    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene     Entrez Gene     Entrez Gene    
Display nearby genome region Chr 2 from 20309349 bp to 30418963 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 202514 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (0.85) HK3 (0.98) HK4 (1.39) HK5 (0.67) HK7 (0.20) HK9 (2.33) HK11 (0.57) HK12 (-0.05) HK13 (1.16) HK14 (1.36) HK15 (1.04) HK16 (0.73) HK18 (-0.53) HK19 (0.98) HK20 (0.20) HK21 (1.32) HK22 (1.24) HK24 (1.02) HK27 (0.85) HK28 (0.69) HK29 (0.46) HK31 (-0.64) HK33 (0.34) HK36 (0.00) HK37 (0.00) HK38 (1.09) HK39 (0.12) HK42 (0.00) HK46 (0.62) HK47 (3.60) HK49 (0.20) HK62 (0.24) HK63 (1.43) HK64 (4.61) HK67 (-0.06) HK84 (0.37) HK85 (3.82) SF1 (0.85) SF12 (3.48) SF15 (-0.70) SF17 (-0.91) SF18 (-0.59) SF21 (-3.04) SF22 (0.52) SF23 (-0.66) SF32 (0.11) SF34 (0.00) SF35 (0.00) SF3 (0.40) SF30 (1.12) HK2 (0.85) HK23 (0.50) HK41 (1.65) SF4 (0.59) SF8 (0.36) SF9 (1.45)