OncoDB.HCC Expression View

Gene name : COPS5
Ensembl ID ENSG00000121022
Description COP9 signalosome complex subunit 5 (EC 3.4.-.-) (Signalosome subunit 5) (SGN5) (Jun activation domain-binding protein 1). [Source:Uniprot/SWISSPROT;Acc:Q92905]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
20 percent with 2 folds change ( 11 up and 0 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- QPCR, IHC, chr. amplification    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 8 from 63117871 bp to 73136785 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 795847 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.70) HK1 (1.82) HK3 (0.59) HK4 (0.86) HK5 (1.06) HK7 (0.11) HK9 (0.52) HK11 (0.90) HK12 (0.85) HK13 (0.27) HK14 (0.23) HK15 (0.70) HK16 (0.72) HK18 (1.23) HK19 (0.37) HK20 (0.30) HK21 (0.61) HK22 (0.11) HK24 (0.86) HK27 (1.09) HK28 (0.59) HK29 (1.05) HK31 (0.07) HK33 (0.14) HK36 (0.67) HK37 (1.25) HK38 (0.61) HK39 (0.00) HK42 (0.53) HK46 (0.63) HK47 (1.60) HK49 (0.06) HK62 (0.20) HK63 (0.58) HK64 (0.31) HK67 (0.46) HK84 (0.00) HK85 (0.23) SF1 (2.06) SF12 (1.50) SF15 (0.99) SF17 (0.46) SF18 (1.24) SF21 (-0.24) SF22 (0.07) SF23 (0.11) SF32 (0.01) SF34 (0.04) SF35 (0.69) SF3 (0.64) SF30 (-0.21) HK2 (0.16) HK23 (0.57) HK41 (1.78) SF4 (0.35) SF8 (0.57) SF9 (0.79)