OncoDB.HCC Expression View

Gene name : PRKDC
Ensembl ID ENSG00000121031
Description DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460). [Source:Uniprot/SWISSPROT;Acc:P78527]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
25 percent with 2 folds change ( 13 up and 0 down in 52 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene     COSMIC    
Display nearby genome region Chr 8 from 43848222 bp to 54035296 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 133637 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (0.90) HK3 (0.88) HK4 (0.38) HK5 (0.82) HK7 (-0.05) HK9 (0.99) HK11 (0.00) HK12 (0.00) HK13 (0.00) HK14 (1.28) HK15 (1.12) HK16 (1.00) HK18 (0.49) HK19 (-0.27) HK20 (0.54) HK21 (0.98) HK22 (0.43) HK24 (-0.03) HK27 (1.11) HK28 (-0.21) HK29 (0.67) HK31 (0.59) HK33 (0.84) HK36 (-0.66) HK37 (0.62) HK38 (-0.03) HK39 (0.54) HK42 (1.36) HK46 (1.45) HK47 (0.00) HK49 (1.74) HK62 (0.19) HK63 (0.57) HK64 (0.41) HK67 (-0.78) HK84 (1.82) HK85 (-0.22) SF1 (0.73) SF12 (0.28) SF15 (-0.67) SF17 (0.52) SF18 (2.21) SF21 (1.42) SF22 (2.23) SF23 (-0.36) SF32 (-0.45) SF34 (0.05) SF35 (1.42) SF3 (0.14) SF30 (0.79) HK2 (0.07) HK23 (-0.10) HK41 (0.83) SF4 (0.42) SF8 (-0.10) SF9 (1.60)