OncoDB.HCC Expression View

Gene name : TNFSF10
Ensembl ID ENSG00000121858
Description Tumor necrosis factor ligand superfamily member 10 (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (Apo-2 ligand) (Apo-2L) (CD253 antigen). [Source:Uniprot/SWISSPROT;Acc:P50591]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
42 percent with 2 folds change ( 7 up and 17 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- Western    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 3 from 168706159 bp to 178723963 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 183811 -- IMAGE clone locate on exon ( blastn )
139226 -- IMAGE clone locate on exon ( tblastx )
203132 -- IMAGE clone locate on exon ( tblastx )
CH2 (-1.17) HK1 (-1.89) HK3 (-0.48) HK4 (-3.88) HK5 (-3.04) HK7 (1.71) HK9 (-0.62) HK11 (-0.06) HK12 (-0.47) HK13 (-0.23) HK14 (-1.28) HK15 (-1.63) HK16 (-0.00) HK18 (-0.09) HK19 (0.84) HK20 (-0.36) HK21 (-0.43) HK22 (-0.38) HK24 (1.03) HK27 (-0.21) HK28 (-1.65) HK29 (-0.30) HK31 (0.93) HK33 (-0.14) HK36 (-1.58) HK37 (-0.24) HK38 (-0.02) HK39 (0.79) HK42 (-1.85) HK46 (0.03) HK47 (-2.70) HK49 (3.44) HK62 (2.23) HK63 (-0.76) HK64 (-0.94) HK67 (-0.10) HK84 (-0.74) HK85 (-0.13) SF1 (0.85) SF12 (-2.51) SF15 (-3.25) SF17 (-1.79) SF18 (-1.01) SF21 (1.64) SF22 (3.93) SF23 (-2.67) SF32 (-0.21) SF34 (0.02) SF35 (0.04) SF3 (-1.65) SF30 (2.24) HK2 (-0.33) HK23 (-0.56) HK41 (-0.95) SF4 (-0.75) SF8 (-1.36) SF9 (-0.16)