OncoDB.HCC Expression View

Gene name : PIK3CA
Ensembl ID ENSG00000121879
Description Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K). [Source:Uniprot/SWISSPROT;Acc:P42336]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
1 percent with 2 folds change ( 1 up and 0 down in 53 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence mutation     Method -- Mutation    
>> Link to terminologies used in OncoDB.HCC
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 3 from 175349005 bp to 185435189 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 345430 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.80) HK1 (-0.21) HK3 (0.48) HK4 (-0.08) HK5 (-0.70) HK7 (-0.10) HK9 (-0.72) HK11 (0.00) HK12 (0.04) HK13 (0.05) HK14 (-0.04) HK15 (0.07) HK16 (0.52) HK18 (0.42) HK19 (0.16) HK20 (0.26) HK21 (1.30) HK22 (-0.14) HK24 (0.02) HK27 (-0.22) HK28 (-0.19) HK29 (-0.18) HK31 (0.62) HK33 (-0.08) HK36 (0.27) HK37 (0.17) HK38 (-0.13) HK39 (-0.04) HK42 (0.21) HK46 (0.09) HK47 (0.26) HK49 (0.21) HK62 (0.24) HK63 (0.21) HK64 (0.51) HK67 (-0.34) HK84 (0.00) HK85 (-0.51) SF1 (-0.52) SF12 (0.15) SF15 (0.01) SF17 (-0.31) SF18 (0.09) SF21 (0.00) SF22 (-0.92) SF23 (0.36) SF32 (-0.04) SF34 (0.00) SF35 (-0.13) SF3 (0.38) SF30 (0.32) HK2 (-0.04) HK23 (0.12) HK41 (0.34) SF4 (0.17) SF8 (-0.05) SF9 (0.46)