OncoDB.HCC Expression View

Gene name : PLG
Ensembl ID ENSG00000122194
Description Plasminogen precursor (EC 3.4.21.7) [Contains: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B]. [Source:Uniprot/SWISSPROT;Acc:P00747]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
59 percent with 2 folds change ( 2 up and 17 down in 32 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- QPCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
down     cDNA microarray - - Shirota et al., Hepatology 33:832 (2001)
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     cDNA Microarray - - Delpuech et al., Oncogene 21:2926 (2002)
Links Entrez Gene    
Display nearby genome region Chr 6 from 156043260 bp to 166094339 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 195040 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (-1.68) HK3 (-1.78) HK4 (-3.03) HK5 (0.00) HK7 (0.00) HK9 (-0.59) HK11 (-0.75) HK12 (-0.46) HK13 (0.00) HK14 (-5.73) HK15 (-4.96) HK16 (0.00) HK18 (-1.67) HK19 (-1.97) HK20 (-0.53) HK21 (-1.35) HK22 (-0.04) HK24 (-1.08) HK27 (-3.67) HK28 (-1.78) HK29 (0.00) HK31 (1.34) HK33 (0.00) HK36 (-1.78) HK37 (0.00) HK38 (-0.11) HK39 (-2.92) HK42 (-2.73) HK46 (0.00) HK47 (0.00) HK49 (0.00) HK62 (-0.93) HK63 (0.76) HK64 (0.35) HK67 (-0.41) HK84 (-1.91) HK85 (-1.57) SF1 (0.00) SF12 (0.00) SF15 (0.00) SF17 (0.00) SF18 (0.00) SF21 (1.62) SF22 (0.00) SF23 (0.00) SF32 (0.00) SF34 (0.68) SF35 (-3.05) SF3 (0.99) SF30 (0.00) HK2 (-0.88) HK23 (0.00) HK41 (0.00) SF4 (0.00) SF8 (0.00) SF9 (0.00)