OncoDB.HCC Expression View

Gene name : PLAU
Ensembl ID ENSG00000122861
Description Urokinase-type plasminogen activator precursor (EC 3.4.21.73) (uPA) (U-plasminogen activator) [Contains: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B]. [Source:Uniprot/SWISSPROT;Acc:P00749]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
25 percent with 2 folds change ( 12 up and 2 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- QPCR, RT-PCR    
>> Link to terminologies used in OncoDB.HCC
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 10 from 70340896 bp to 80347260 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 714106 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.87) HK1 (0.97) HK3 (1.00) HK4 (0.51) HK5 (0.55) HK7 (0.00) HK9 (1.81) HK11 (0.40) HK12 (-0.11) HK13 (-0.71) HK14 (1.41) HK15 (0.17) HK16 (0.77) HK18 (-0.12) HK19 (0.03) HK20 (-0.08) HK21 (1.25) HK22 (-0.28) HK24 (0.53) HK27 (2.60) HK28 (-0.01) HK29 (0.32) HK31 (-0.30) HK33 (0.19) HK36 (1.05) HK37 (0.49) HK38 (0.32) HK39 (1.38) HK42 (0.11) HK46 (-0.69) HK47 (1.00) HK49 (-0.21) HK62 (1.43) HK63 (-0.82) HK64 (-0.19) HK67 (-0.76) HK84 (2.36) HK85 (-0.84) SF1 (0.57) SF12 (0.74) SF15 (-0.76) SF17 (-2.52) SF18 (1.90) SF21 (0.55) SF22 (1.56) SF23 (-0.65) SF32 (-1.12) SF34 (-0.14) SF35 (1.25) SF3 (-0.43) SF30 (0.75) HK2 (-0.34) HK23 (1.85) HK41 (0.17) SF4 (0.38) SF8 (0.90) SF9 (0.06)