OncoDB.HCC Expression View

Gene name : CDKN2C
Ensembl ID ENSG00000123080
Description Cyclin-dependent kinase 6 inhibitor (p18-INK6) (Cyclin-dependent kinase 4 inhibitor C) (p18-INK4c). [Source:Uniprot/SWISSPROT;Acc:P42773]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
75 percent with 2 folds change ( 39 up and 1 down in 53 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- IHC    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 1 from 46199005 bp to 56212893 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 291057 -- IMAGE clone locate on exon ( tblastx )
CH2 (1.06) HK1 (0.28) HK3 (2.22) HK4 (1.65) HK5 (0.00) HK7 (3.74) HK9 (3.26) HK11 (0.93) HK12 (0.50) HK13 (3.40) HK14 (2.83) HK15 (1.23) HK16 (3.58) HK18 (0.35) HK19 (0.00) HK20 (1.89) HK21 (0.00) HK22 (-4.46) HK24 (1.68) HK27 (2.20) HK28 (0.57) HK29 (2.52) HK31 (2.22) HK33 (1.38) HK36 (1.47) HK37 (0.96) HK38 (1.17) HK39 (3.08) HK42 (3.67) HK46 (2.27) HK47 (-0.36) HK49 (1.06) HK62 (2.41) HK63 (3.49) HK64 (2.24) HK67 (0.03) HK84 (2.00) HK85 (7.35) SF1 (1.45) SF12 (3.70) SF15 (-0.42) SF17 (3.43) SF18 (0.00) SF21 (1.82) SF22 (5.31) SF23 (1.10) SF32 (1.41) SF34 (2.78) SF35 (0.00) SF3 (2.47) SF30 (0.00) HK2 (-0.72) HK23 (1.11) HK41 (2.14) SF4 (1.04) SF8 (0.82) SF9 (1.97)