OncoDB.HCC Expression View

Gene name : NR4A1
Ensembl ID ENSG00000123358
Description Orphan nuclear receptor NR4A1 (Orphan nuclear receptor HMR) (Early response protein NAK1) (TR3 orphan receptor) (ST-59). [Source:Uniprot/SWISSPROT;Acc:P22736]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
40 percent with 2 folds change ( 1 up and 21 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     cDNA Microarray - - Honda et al., Gastroenterology 120:955(2001)
up     cDNA microarray - - Shirota et al., Hepatology 33:832 (2001)
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene     Entrez Gene    
Display nearby genome region Chr 12 from 45717766 bp to 55739552 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 309893 -- IMAGE clone locate on exon ( blastn )
CH2 (-1.29) HK1 (-1.99) HK3 (-0.53) HK4 (-1.86) HK5 (-1.28) HK7 (0.32) HK9 (-0.20) HK11 (0.00) HK12 (-1.38) HK13 (-2.11) HK14 (-2.01) HK15 (-0.94) HK16 (-1.34) HK18 (-0.93) HK19 (-0.97) HK20 (-0.19) HK21 (0.02) HK22 (-0.38) HK24 (-0.76) HK27 (-0.70) HK28 (-0.96) HK29 (-0.84) HK31 (-0.28) HK33 (0.02) HK36 (-0.07) HK37 (-1.72) HK38 (-2.18) HK39 (-0.99) HK42 (-0.40) HK46 (-2.26) HK47 (-3.14) HK49 (0.98) HK62 (0.78) HK63 (-1.47) HK64 (-1.13) HK67 (0.00) HK84 (-0.16) HK85 (-0.05) SF1 (-1.45) SF12 (-0.60) SF15 (-1.27) SF17 (-1.06) SF18 (-0.36) SF21 (1.01) SF22 (-0.93) SF23 (-2.00) SF32 (-0.88) SF34 (-0.83) SF35 (-0.29) SF3 (0.13) SF30 (-1.13) HK2 (-1.38) HK23 (-0.39) HK41 (-1.88) SF4 (-0.88) SF8 (-0.95) SF9 (-0.96)