OncoDB.HCC Expression View

Gene name : PCK1
Ensembl ID ENSG00000124253
Description Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (EC 4.1.1.32) (Phosphoenolpyruvate carboxylase) (PEPCK-C). [Source:Uniprot/SWISSPROT;Acc:P35558]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
59 percent with 2 folds change ( 7 up and 27 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     cDNA Microarray - - Xu et al., Cancer Res. 61:3176 (2001)
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Affy. Microarray - - Iizuka et al., J Cancer Res Clin Oncol 132:473 (2006)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 20 from 50569543 bp to 60574922 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 742082 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.13) HK1 (-0.79) HK3 (-2.42) HK4 (0.90) HK5 (-0.23) HK7 (-1.26) HK9 (-1.51) HK11 (0.76) HK12 (-2.72) HK13 (1.32) HK14 (-3.77) HK15 (-4.30) HK16 (-0.75) HK18 (-1.04) HK19 (-1.01) HK20 (-1.06) HK21 (-0.84) HK22 (0.87) HK24 (-1.16) HK27 (-4.54) HK28 (0.82) HK29 (-1.00) HK31 (-0.59) HK33 (0.93) HK36 (1.55) HK37 (-1.78) HK38 (0.95) HK39 (-4.10) HK42 (-2.27) HK46 (-1.72) HK47 (-2.31) HK49 (1.15) HK62 (-1.48) HK63 (-1.19) HK64 (-2.01) HK67 (-0.63) HK84 (-0.44) HK85 (2.88) SF1 (1.17) SF12 (-3.46) SF15 (1.23) SF17 (0.80) SF18 (-3.34) SF21 (-0.61) SF22 (0.04) SF23 (0.69) SF32 (0.63) SF34 (0.07) SF35 (-4.19) SF3 (0.06) SF30 (1.46) HK2 (-1.66) HK23 (-3.26) HK41 (0.47) SF4 (-2.89) SF8 (-2.44) SF9 (-2.77)