OncoDB.HCC Expression View

Gene name : CDKN1A
Ensembl ID ENSG00000124762
Description Cyclin-dependent kinase inhibitor 1 (p21) (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6). [Source:Uniprot/SWISSPROT;Acc:P38936]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
57 percent with 2 folds change ( 5 up and 19 down in 42 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- IHC, RT-PCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     cDNA Microarray - - Honda et al., Gastroenterology 120:955(2001)
down     cDNA Microarray - - Delpuech et al., Oncogene 21:2926 (2002)
down     PCR Array - - Kurokawa et al., J Hepatol. 39:1004 (2003)
Links Entrez Gene     Entrez Gene     Entrez Gene    
Display nearby genome region Chr 6 from 31754413 bp to 41763094 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 268652 -- IMAGE clone locate on exon ( tblastx )
CH2 (-2.46) HK1 (0.64) HK3 (-0.30) HK4 (-1.53) HK5 (0.00) HK7 (0.00) HK9 (0.10) HK11 (-0.64) HK12 (-0.91) HK13 (1.13) HK14 (1.92) HK15 (1.14) HK16 (-0.35) HK18 (-0.21) HK19 (-2.47) HK20 (1.08) HK21 (0.00) HK22 (-1.62) HK24 (-1.54) HK27 (0.43) HK28 (-2.40) HK29 (-0.51) HK31 (0.00) HK33 (-1.16) HK36 (0.05) HK37 (-2.10) HK38 (1.44) HK39 (0.69) HK42 (0.40) HK46 (0.00) HK47 (0.00) HK49 (0.00) HK62 (-1.44) HK63 (0.25) HK64 (0.62) HK67 (-2.24) HK84 (0.00) HK85 (-1.20) SF1 (-0.98) SF12 (-1.68) SF15 (0.00) SF17 (0.00) SF18 (-1.21) SF21 (0.00) SF22 (-2.17) SF23 (0.00) SF32 (0.35) SF34 (-1.33) SF35 (-1.35) SF3 (-2.61) SF30 (0.33) HK2 (-1.80) HK23 (0.00) HK41 (-1.79) SF4 (0.00) SF8 (0.00) SF9 (0.00)