OncoDB.HCC Expression View

Gene name : IRF1
Ensembl ID ENSG00000125347
Description Interferon regulatory factor 1 (IRF-1). [Source:Uniprot/SWISSPROT;Acc:P10914]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
21 percent with 2 folds change ( 4 up and 8 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- RT-PCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 5 from 126845200 bp to 136854389 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 740476 -- IMAGE clone locate on exon ( tblastx )
CH2 (-1.23) HK1 (0.89) HK3 (-0.82) HK4 (-0.46) HK5 (-0.59) HK7 (-0.91) HK9 (-0.36) HK11 (0.33) HK12 (0.13) HK13 (-0.65) HK14 (-0.15) HK15 (0.38) HK16 (1.12) HK18 (-0.09) HK19 (-1.21) HK20 (0.25) HK21 (0.08) HK22 (0.55) HK24 (0.21) HK27 (1.30) HK28 (-0.93) HK29 (-0.45) HK31 (1.17) HK33 (-0.10) HK36 (-0.73) HK37 (-0.69) HK38 (0.56) HK39 (0.21) HK42 (-2.01) HK46 (-0.70) HK47 (0.00) HK49 (0.95) HK62 (-0.76) HK63 (-0.51) HK64 (-0.79) HK67 (-0.06) HK84 (0.76) HK85 (-0.63) SF1 (0.27) SF12 (-1.24) SF15 (-1.04) SF17 (-1.20) SF18 (-0.86) SF21 (-0.17) SF22 (-1.41) SF23 (-0.47) SF32 (-0.03) SF34 (-0.56) SF35 (0.54) SF3 (-0.16) SF30 (1.13) HK2 (-1.77) HK23 (0.26) HK41 (-0.60) SF4 (0.00) SF8 (0.96) SF9 (0.49)