OncoDB.HCC Expression View

Gene name : MAP2K2
Ensembl ID ENSG00000126934
Description Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2). [Source:Uniprot/SWISSPROT;Acc:P36507]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
20 percent with 2 folds change ( 8 up and 3 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- Western    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 19 from 0 bp to 9075126 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 769579 -- IMAGE clone locate on exon ( blastn )
CH2 (0.27) HK1 (0.46) HK3 (-0.35) HK4 (0.00) HK5 (1.38) HK7 (0.96) HK9 (0.45) HK11 (0.05) HK12 (1.35) HK13 (0.31) HK14 (0.70) HK15 (0.95) HK16 (0.88) HK18 (0.13) HK19 (1.22) HK20 (0.59) HK21 (0.36) HK22 (0.16) HK24 (0.08) HK27 (0.00) HK28 (0.43) HK29 (-0.55) HK31 (1.03) HK33 (0.13) HK36 (0.52) HK37 (0.21) HK38 (0.44) HK39 (0.36) HK42 (-0.00) HK46 (0.05) HK47 (-1.71) HK49 (-1.05) HK62 (-0.05) HK63 (-1.02) HK64 (1.50) HK67 (0.00) HK84 (0.00) HK85 (0.02) SF1 (0.62) SF12 (0.20) SF15 (-0.08) SF17 (-0.41) SF18 (1.17) SF21 (-0.38) SF22 (1.12) SF23 (0.17) SF32 (0.75) SF34 (0.14) SF35 (0.30) SF3 (1.55) SF30 (0.79) HK2 (0.23) HK23 (0.97) HK41 (-0.60) SF4 (0.87) SF8 (0.18) SF9 (0.31)