OncoDB.HCC Expression View

Gene name : TSPAN8
Ensembl ID ENSG00000127324
Description Tetraspanin-8 (Tspan-8) (Transmembrane 4 superfamily member 3) (Tumor- associated antigen CO-029). [Source:Uniprot/SWISSPROT;Acc:P19075]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
61 percent with 2 folds change ( 27 up and 5 down in 52 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- QPCR, IHC    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 12 from 64805144 bp to 74838046 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 509731 -- IMAGE clone locate on exon ( tblastx )
CH2 (-3.81) HK1 (0.73) HK3 (1.48) HK4 (-0.95) HK5 (1.52) HK7 (1.52) HK9 (0.82) HK11 (2.88) HK12 (1.01) HK13 (-1.78) HK14 (1.69) HK15 (1.15) HK16 (-0.73) HK18 (0.47) HK19 (2.09) HK20 (1.02) HK21 (0.74) HK22 (1.96) HK24 (2.62) HK27 (0.91) HK28 (0.42) HK29 (1.13) HK31 (0.55) HK33 (-1.09) HK36 (0.00) HK37 (1.53) HK38 (0.29) HK39 (0.00) HK42 (2.49) HK46 (-0.25) HK47 (0.92) HK49 (2.42) HK62 (-0.88) HK63 (2.29) HK64 (0.00) HK67 (0.18) HK84 (1.65) HK85 (-0.26) SF1 (2.82) SF12 (0.99) SF15 (-1.56) SF17 (0.00) SF18 (4.43) SF21 (1.63) SF22 (4.02) SF23 (-2.49) SF32 (4.43) SF34 (1.90) SF35 (1.21) SF3 (0.52) SF30 (0.00) HK2 (0.71) HK23 (0.95) HK41 (3.67) SF4 (2.73) SF8 (1.11) SF9 (-0.66)