OncoDB.HCC Expression View

Gene name : ECHS1
Ensembl ID ENSG00000127884
Description Enoyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.17) (Short chain enoyl-CoA hydratase) (SCEH) (Enoyl-CoA hydratase 1). [Source:Uniprot/SWISSPROT;Acc:P30084]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
28 percent with 2 folds change ( 0 up and 16 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
down     cDNA Microarray - - Xu et al., Cancer Res. 61:3176 (2001)
down     PCR Array - - Kurokawa et al., J Hepatol. 39:1004 (2003)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
down     Proteomic Analysis - - Li et al., Mol Cell Proteomics 3:399 (2004)
down     Proteomic Analysis - - Yokoyama et al., Proteomics 4:21111 (2004)
down     Proteomic Analysis - - Liang et al., Proteomics 5:2258 (2005)
down     Proteomic Analysis - - Liang et al., Proteomics 5:2258 (2005)
down     Proteomic Analysis - - Blanc et al., Proteomics 5:37788 (2005)
Links Entrez Gene    
Display nearby genome region Chr 10 from 130025974 bp to 135374737 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 745542 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.77) HK1 (-0.72) HK3 (-1.03) HK4 (0.92) HK5 (-0.72) HK7 (-0.99) HK9 (-0.90) HK11 (-1.43) HK12 (-0.81) HK13 (-0.12) HK14 (-1.41) HK15 (-0.42) HK16 (-0.84) HK18 (-0.76) HK19 (-1.93) HK20 (-0.18) HK21 (-1.49) HK22 (-0.36) HK24 (-0.48) HK27 (-1.17) HK28 (-0.01) HK29 (-0.37) HK31 (0.21) HK33 (-0.32) HK36 (-0.96) HK37 (-0.63) HK38 (-0.84) HK39 (-2.13) HK42 (0.27) HK46 (-0.01) HK47 (-1.69) HK49 (-0.27) HK62 (-0.48) HK63 (-0.42) HK64 (-1.11) HK67 (-0.20) HK84 (0.00) HK85 (-0.82) SF1 (-0.78) SF12 (-0.69) SF15 (-0.88) SF17 (-0.14) SF18 (-1.76) SF21 (-1.16) SF22 (-0.18) SF23 (0.31) SF32 (0.20) SF34 (0.90) SF35 (-1.83) SF3 (-0.93) SF30 (-1.47) HK2 (-1.52) HK23 (-0.96) HK41 (-1.56) SF4 (-0.79) SF8 (-0.71) SF9 (-2.25)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).