OncoDB.HCC Expression View

Gene name : SMO
Ensembl ID ENSG00000128602
Description Smoothened homolog precursor (SMO) (Gx protein). [Source:Uniprot/SWISSPROT;Acc:Q99835]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
27 percent with 2 folds change ( 15 up and 0 down in 54 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- QPCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 7 from 123615949 bp to 133640617 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 530958 -- IMAGE clone locate on exon ( tblastx )
CH2 (1.24) HK1 (-0.28) HK3 (-0.11) HK4 (0.00) HK5 (0.24) HK7 (1.98) HK9 (0.64) HK11 (-0.27) HK12 (1.12) HK13 (0.39) HK14 (1.30) HK15 (1.41) HK16 (-0.18) HK18 (-0.37) HK19 (0.50) HK20 (0.92) HK21 (0.14) HK22 (-0.36) HK24 (0.95) HK27 (0.01) HK28 (1.00) HK29 (1.10) HK31 (0.75) HK33 (0.18) HK36 (0.51) HK37 (1.28) HK38 (0.58) HK39 (0.93) HK42 (1.29) HK46 (1.21) HK47 (-0.62) HK49 (-0.12) HK62 (0.17) HK63 (1.04) HK64 (0.64) HK67 (0.86) HK84 (0.16) HK85 (1.05) SF1 (0.36) SF12 (-0.16) SF15 (0.84) SF17 (0.49) SF18 (0.00) SF21 (0.14) SF22 (0.00) SF23 (0.07) SF32 (0.69) SF34 (0.89) SF35 (1.48) SF3 (1.42) SF30 (0.28) HK2 (1.51) HK23 (0.27) HK41 (0.12) SF4 (0.38) SF8 (0.14) SF9 (0.17)