OncoDB.HCC Expression View

Gene name : PARP2
Ensembl ID ENSG00000129484
Description Poly [ADP-ribose] polymerase 2 (EC 2.4.2.30) (PARP-2) (NAD(+) ADP- ribosyltransferase 2) (Poly[ADP-ribose] synthetase 2) (pADPRT-2) (hPARP-2). [Source:Uniprot/SWISSPROT;Acc:Q9UGN5]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
35 percent with 2 folds change ( 18 up and 1 down in 53 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 14 from 14881634 bp to 24895902 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 51469 -- IMAGE clone locate on exon ( tblastx )
CH2 (1.87) HK1 (-0.83) HK3 (1.66) HK4 (1.26) HK5 (-0.08) HK7 (-0.37) HK9 (1.55) HK11 (0.00) HK12 (0.35) HK13 (1.24) HK14 (1.05) HK15 (0.86) HK16 (0.77) HK18 (-0.29) HK19 (-0.07) HK20 (-0.01) HK21 (-0.02) HK22 (1.86) HK24 (0.22) HK27 (0.43) HK28 (1.73) HK29 (1.11) HK31 (1.16) HK33 (0.72) HK36 (0.00) HK37 (2.11) HK38 (-0.09) HK39 (0.39) HK42 (0.00) HK46 (0.24) HK47 (2.07) HK49 (-0.29) HK62 (0.08) HK63 (-0.08) HK64 (0.49) HK67 (0.00) HK84 (0.00) HK85 (1.67) SF1 (0.07) SF12 (0.78) SF15 (-1.17) SF17 (1.02) SF18 (1.12) SF21 (-0.73) SF22 (0.85) SF23 (0.55) SF32 (0.20) SF34 (-0.36) SF35 (1.48) SF3 (1.31) SF30 (0.91) HK2 (0.87) HK23 (0.02) HK41 (1.64) SF4 (0.54) SF8 (-0.50) SF9 (0.47)