OncoDB.HCC Expression View

Gene name : IGHG3
Ensembl ID ENSG00000130076
Description Ig gamma-1 chain C region. [Source:Uniprot/SWISSPROT;Acc:P01857]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
63 percent with 2 folds change ( 9 up and 27 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     cDNA Microarray - - Delpuech et al., Oncogene 21:2926 (2002)
down     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
up     Proteomic Analysis - - Li et al., Mol Cell Proteomics 3:399 (2004)
Display nearby genome region Chr 14 from 100244506 bp to 106368585 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 181831 -- IMAGE clone locate on exon ( tblastx )
289337 -- IMAGE clone locate on exon ( tblastx )
855745 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.54) HK1 (-2.11) HK3 (-0.36) HK4 (-4.12) HK5 (-0.54) HK7 (2.41) HK9 (-7.49) HK11 (0.80) HK12 (-0.96) HK13 (-1.24) HK14 (-3.80) HK15 (-1.26) HK16 (0.95) HK18 (-0.24) HK19 (0.57) HK20 (-2.88) HK21 (-0.30) HK22 (-1.14) HK24 (-1.61) HK27 (-0.76) HK28 (-5.36) HK29 (-0.10) HK31 (-2.91) HK33 (-2.80) HK36 (-0.72) HK37 (-6.36) HK38 (-2.23) HK39 (1.40) HK42 (-4.01) HK46 (-0.50) HK47 (-1.38) HK49 (2.69) HK62 (-0.42) HK63 (-4.41) HK64 (-2.36) HK67 (-1.69) HK84 (-0.16) HK85 (1.95) SF1 (-2.91) SF12 (-2.19) SF15 (-3.57) SF17 (-2.78) SF18 (-0.40) SF21 (1.02) SF22 (7.63) SF23 (-0.43) SF32 (-2.58) SF34 (1.77) SF35 (0.26) SF3 (0.05) SF30 (4.40) HK2 (1.54) HK23 (-2.77) HK41 (-3.72) SF4 (-0.01) SF8 (-4.11) SF9 (0.71)