OncoDB.HCC Expression View

Gene name : APOE
Ensembl ID ENSG00000130203
Description Apolipoprotein E precursor (Apo-E). [Source:Uniprot/SWISSPROT;Acc:P02649]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
40 percent with 2 folds change ( 13 up and 10 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- IHC, Western    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     Proteomic Analysis - - Blanc et al., Proteomics 5:37788 (2005)
Links Entrez Gene    
Display nearby genome region Chr 19 from 45100879 bp to 55104489 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 753610 -- IMAGE clone locate on exon ( tblastx )
1590208 -- IMAGE clone locate on exon ( tblastx )
CH2 (2.02) HK1 (-0.62) HK3 (-1.63) HK4 (-0.47) HK5 (-0.14) HK7 (0.39) HK9 (0.16) HK11 (-0.34) HK12 (0.22) HK13 (-0.16) HK14 (-0.52) HK15 (-0.02) HK16 (-0.65) HK18 (-0.47) HK19 (-4.87) HK20 (-0.40) HK21 (-1.13) HK22 (-0.21) HK24 (1.09) HK27 (-2.18) HK28 (0.19) HK29 (-1.87) HK31 (1.52) HK33 (-0.40) HK36 (0.39) HK37 (0.41) HK38 (1.04) HK39 (-0.81) HK42 (-0.90) HK46 (-0.37) HK47 (-5.06) HK49 (2.30) HK62 (0.01) HK63 (0.10) HK64 (0.96) HK67 (1.25) HK84 (-0.68) HK85 (-1.45) SF1 (0.53) SF12 (3.46) SF15 (-0.19) SF17 (6.30) SF18 (2.01) SF21 (1.16) SF22 (2.80) SF23 (-1.63) SF32 (1.78) SF34 (0.78) SF35 (0.11) SF3 (1.08) SF30 (-1.33) HK2 (-0.55) HK23 (0.60) HK41 (0.02) SF4 (0.52) SF8 (-0.10) SF9 (-1.36)