OncoDB.HCC Expression View

Gene name : PLVAP
Ensembl ID ENSG00000130300
Description Plasmalemma vesicle-associated protein (Plasmalemma vesicle protein 1) (PV-1) (Fenestrated endothelial-linked structure protein). [Source:Uniprot/SWISSPROT;Acc:Q9BX97]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
80 percent with 2 folds change ( 33 up and 0 down in 41 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
up     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
Links Entrez Gene    
Display nearby genome region Chr 19 from 12323264 bp to 22349159 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 666292 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (2.92) HK3 (1.89) HK4 (0.00) HK5 (0.00) HK7 (0.00) HK9 (0.00) HK11 (1.99) HK12 (0.27) HK13 (1.38) HK14 (0.33) HK15 (1.28) HK16 (0.57) HK18 (0.48) HK19 (1.99) HK20 (0.90) HK21 (1.28) HK22 (0.00) HK24 (3.76) HK27 (1.55) HK28 (3.33) HK29 (1.06) HK31 (3.92) HK33 (2.50) HK36 (3.00) HK37 (3.03) HK38 (3.38) HK39 (1.94) HK42 (3.86) HK46 (3.80) HK47 (0.00) HK49 (0.00) HK62 (2.74) HK63 (0.05) HK64 (0.00) HK67 (3.97) HK84 (1.72) HK85 (0.00) SF1 (0.00) SF12 (1.44) SF15 (0.00) SF17 (1.69) SF18 (4.12) SF21 (5.04) SF22 (0.00) SF23 (0.69) SF32 (4.68) SF34 (2.30) SF35 (0.00) SF3 (0.12) SF30 (0.00) HK2 (0.00) HK23 (1.54) HK41 (3.88) SF4 (3.49) SF8 (4.42) SF9 (2.76)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).