OncoDB.HCC Expression View

Gene name : CYP2E1
Ensembl ID ENSG00000130649
Description Cytochrome P450 2E1 (EC 1.14.14.1) (CYPIIE1) (P450-J). [Source:Uniprot/SWISSPROT;Acc:P05181]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
37 percent with 2 folds change ( 2 up and 9 down in 29 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- QPCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     cDNA Microarray - - Xu et al., Cancer Res. 61:3176 (2001)
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
down     Proteomic Analysis - - Li et al., Mol Cell Proteomics 3:399 (2004)
Links Entrez Gene    
Display nearby genome region Chr 10 from 130190857 bp to 135374737 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 179403 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (1.18) HK3 (-0.34) HK4 (-1.22) HK5 (0.00) HK7 (0.00) HK9 (0.00) HK11 (-0.17) HK12 (-0.63) HK13 (-1.89) HK14 (-1.31) HK15 (-0.42) HK16 (-0.86) HK18 (-0.34) HK19 (-0.25) HK20 (0.00) HK21 (-1.22) HK22 (-0.19) HK24 (-0.30) HK27 (-1.96) HK28 (-1.19) HK29 (-0.26) HK31 (0.00) HK33 (0.00) HK36 (0.64) HK37 (0.00) HK38 (-0.43) HK39 (0.00) HK42 (-0.57) HK46 (0.00) HK47 (0.00) HK49 (-1.65) HK62 (0.00) HK63 (-1.25) HK64 (0.00) HK67 (0.00) HK84 (0.00) HK85 (0.00) SF1 (0.00) SF12 (0.00) SF15 (0.00) SF17 (0.00) SF18 (0.00) SF21 (0.00) SF22 (0.00) SF23 (0.00) SF32 (0.00) SF34 (0.44) SF35 (0.00) SF3 (-0.60) SF30 (1.03) HK2 (0.24) HK23 (0.00) HK41 (0.00) SF4 (0.39) SF8 (0.49) SF9 (-1.40)