OncoDB.HCC Expression View

Gene name : ASS1
Ensembl ID ENSG00000130707
Description Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase). [Source:Uniprot/SWISSPROT;Acc:P00966]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
71 percent with 2 folds change ( 2 up and 39 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- QPCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     cDNA Microarray - - Xu et al., Cancer Res. 61:3176 (2001)
down     Affy. Microarray - - Iizuka et al., J Cancer Res Clin Oncol 132:473 (2006)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
down     Proteomic Analysis - - Kim et al., Clin Cancer Research 9:5493 (2003)
down     Proteomic Analysis - - Li et al., Mol Cell Proteomics 3:399 (2004)
Links Entrez Gene     Entrez Gene     Entrez Gene     Entrez Gene    
Display nearby genome region Chr 9 from 127310137 bp to 137366482 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 882522 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.62) HK1 (-1.24) HK3 (-1.78) HK4 (-1.96) HK5 (-1.80) HK7 (-4.18) HK9 (-1.02) HK11 (-2.63) HK12 (-3.43) HK13 (0.78) HK14 (-2.38) HK15 (-2.07) HK16 (-1.10) HK18 (-0.66) HK19 (-0.57) HK20 (-2.14) HK21 (-1.88) HK22 (0.05) HK24 (-0.68) HK27 (-2.65) HK28 (0.01) HK29 (-2.11) HK31 (0.64) HK33 (-1.05) HK36 (-0.95) HK37 (-2.37) HK38 (-1.13) HK39 (-4.10) HK42 (-1.79) HK46 (-1.94) HK47 (-1.47) HK49 (-1.06) HK62 (-0.35) HK63 (-1.05) HK64 (-1.89) HK67 (-1.69) HK84 (-1.31) HK85 (-1.54) SF1 (-1.85) SF12 (0.00) SF15 (-1.38) SF17 (1.20) SF18 (-2.36) SF21 (-0.54) SF22 (2.93) SF23 (0.18) SF32 (-0.78) SF34 (-1.04) SF35 (-1.56) SF3 (-0.67) SF30 (-3.34) HK2 (-0.91) HK23 (-1.22) HK41 (-1.54) SF4 (-1.24) SF8 (-1.61) SF9 (-2.71)