OncoDB.HCC Expression View

Gene name : ACLY
Ensembl ID ENSG00000131473
Description ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme). [Source:Uniprot/SWISSPROT;Acc:P53396]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
42 percent with 2 folds change ( 23 up and 1 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
up     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
up     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 17 from 32276710 bp to 42328798 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 45327 -- IMAGE clone locate on exon ( tblastx )
502622 -- IMAGE clone locate on exon ( tblastx )
CH2 (2.14) HK1 (0.90) HK3 (-0.36) HK4 (0.14) HK5 (0.93) HK7 (0.80) HK9 (1.02) HK11 (1.62) HK12 (0.72) HK13 (1.67) HK14 (2.53) HK15 (1.94) HK16 (0.89) HK18 (1.23) HK19 (1.57) HK20 (0.62) HK21 (1.54) HK22 (1.94) HK24 (0.31) HK27 (0.27) HK28 (1.40) HK29 (0.73) HK31 (0.19) HK33 (0.79) HK36 (0.64) HK37 (0.95) HK38 (0.51) HK39 (1.00) HK42 (0.66) HK46 (0.57) HK47 (1.31) HK49 (0.28) HK62 (0.42) HK63 (0.24) HK64 (1.43) HK67 (0.92) HK84 (2.36) HK85 (0.94) SF1 (1.32) SF12 (1.91) SF15 (0.24) SF17 (-1.05) SF18 (-0.06) SF21 (-0.29) SF22 (0.87) SF23 (-0.80) SF32 (1.34) SF34 (1.23) SF35 (0.92) SF3 (0.52) SF30 (0.70) HK2 (1.96) HK23 (1.24) HK41 (0.39) SF4 (-0.07) SF8 (1.05) SF9 (1.42)