OncoDB.HCC Expression View

Gene name : P11388-3
Ensembl ID ENSG00000131747
Description TOP2A_HUMAN Isoform 2 of P11388 - Homo sapiens (Human) [Source:Uniprot/Varsplic;Acc:P11388-2]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
42 percent with 2 folds change ( 24 up and 0 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- QPCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links COSMIC    
Display nearby genome region Chr 17 from 30798321 bp to 40827695 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 301388 -- IMAGE clone locate on exon ( tblastx )
366971 -- IMAGE clone locate on exon ( tblastx )
825470 -- IMAGE clone locate on exon ( tblastx )
CH2 (1.13) HK1 (-0.52) HK3 (1.09) HK4 (0.72) HK5 (0.14) HK7 (0.53) HK9 (1.59) HK11 (0.59) HK12 (0.15) HK13 (0.52) HK14 (1.41) HK15 (-0.46) HK16 (0.63) HK18 (0.14) HK19 (0.73) HK20 (1.61) HK21 (0.54) HK22 (0.70) HK24 (0.58) HK27 (1.17) HK28 (-0.05) HK29 (1.21) HK31 (-0.01) HK33 (0.52) HK36 (0.58) HK37 (1.24) HK38 (-0.07) HK39 (1.83) HK42 (2.21) HK46 (2.27) HK47 (1.08) HK49 (0.78) HK62 (0.73) HK63 (1.15) HK64 (0.51) HK67 (0.24) HK84 (1.08) HK85 (3.51) SF1 (-0.06) SF12 (2.09) SF15 (-0.30) SF17 (0.95) SF18 (1.01) SF21 (1.16) SF22 (1.76) SF23 (0.06) SF32 (0.14) SF34 (2.43) SF35 (1.47) SF3 (1.47) SF30 (2.66) HK2 (0.24) HK23 (-0.28) HK41 (0.60) SF4 (0.50) SF8 (0.28) SF9 (2.25)