OncoDB.HCC Expression View

Gene name : RAF1
Ensembl ID ENSG00000132155
Description RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf). [Source:Uniprot/SWISSPROT;Acc:P04049]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
0 percent with 2 folds change ( 0 up and 0 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- QPCR,Western    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 3 from 7600108 bp to 17680678 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 257414 -- IMAGE clone locate on exon ( tblastx )
267634 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.29) HK1 (0.01) HK3 (-0.04) HK4 (0.32) HK5 (-0.17) HK7 (0.11) HK9 (0.65) HK11 (0.69) HK12 (0.50) HK13 (0.27) HK14 (0.55) HK15 (0.36) HK16 (0.05) HK18 (0.27) HK19 (0.32) HK20 (0.20) HK21 (0.05) HK22 (-0.15) HK24 (0.22) HK27 (-0.07) HK28 (0.09) HK29 (-0.17) HK31 (0.47) HK33 (0.13) HK36 (-0.12) HK37 (0.45) HK38 (0.72) HK39 (0.70) HK42 (0.99) HK46 (0.15) HK47 (0.56) HK49 (-0.13) HK62 (0.23) HK63 (0.74) HK64 (0.52) HK67 (0.47) HK84 (-0.22) HK85 (0.82) SF1 (0.33) SF12 (0.22) SF15 (-0.26) SF17 (-0.29) SF18 (-0.16) SF21 (-0.05) SF22 (0.29) SF23 (0.28) SF32 (0.84) SF34 (-0.05) SF35 (0.10) SF3 (0.63) SF30 (0.38) HK2 (0.13) HK23 (-0.08) HK41 (-0.23) SF4 (0.11) SF8 (0.08) SF9 (0.16)