OncoDB.HCC Expression View

Gene name : PCNA
Ensembl ID ENSG00000132646
Description Proliferating cell nuclear antigen (PCNA) (Cyclin). [Source:Uniprot/SWISSPROT;Acc:P12004]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
70 percent with 2 folds change ( 39 up and 1 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- Western    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
up     Proteomic Analysis - - Li et al., Proteomics 5:1125 (2005)
Links Entrez Gene     Entrez Gene     COSMIC    
Display nearby genome region Chr 20 from 43599 bp to 10055270 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 43229 -- IMAGE clone locate on exon ( tblastx )
789182 -- IMAGE clone locate on exon ( tblastx )
CH2 (2.25) HK1 (2.54) HK3 (2.29) HK4 (1.28) HK5 (-0.28) HK7 (2.24) HK9 (2.77) HK11 (0.89) HK12 (0.83) HK13 (2.20) HK14 (2.58) HK15 (0.05) HK16 (1.66) HK18 (0.21) HK19 (1.42) HK20 (2.06) HK21 (1.14) HK22 (1.32) HK24 (1.38) HK27 (1.31) HK28 (-0.17) HK29 (0.39) HK31 (1.21) HK33 (0.90) HK36 (1.35) HK37 (2.13) HK38 (2.29) HK39 (2.58) HK42 (2.94) HK46 (1.98) HK47 (1.76) HK49 (0.56) HK62 (0.41) HK63 (1.85) HK64 (1.88) HK67 (1.01) HK84 (1.78) HK85 (-8.11) SF1 (1.36) SF12 (2.08) SF15 (1.06) SF17 (-0.00) SF18 (0.10) SF21 (-0.94) SF22 (1.90) SF23 (0.46) SF32 (1.46) SF34 (2.39) SF35 (2.42) SF3 (1.64) SF30 (2.48) HK2 (0.46) HK23 (-0.02) HK41 (1.60) SF4 (1.06) SF8 (0.23) SF9 (2.01)