OncoDB.HCC Expression View

Gene name : APCS
Ensembl ID ENSG00000132703
Description Serum amyloid P-component precursor (SAP) (9.5S alpha-1-glycoprotein) [Contains: Serum amyloid P-component(1-203)]. [Source:Uniprot/SWISSPROT;Acc:P02743]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
50 percent with 2 folds change ( 6 up and 21 down in 54 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
down     Proteomic Analysis - - Blanc et al., Proteomics 5:37788 (2005)
Links Entrez Gene    
Display nearby genome region Chr 1 from 152824240 bp to 162825284 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 201650 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.35) HK1 (-0.41) HK3 (-2.03) HK4 (-0.45) HK5 (-0.57) HK7 (-1.29) HK9 (-1.69) HK11 (-0.15) HK12 (-0.88) HK13 (0.32) HK14 (0.14) HK15 (-0.62) HK16 (0.81) HK18 (-1.01) HK19 (0.27) HK20 (-1.23) HK21 (0.00) HK22 (2.62) HK24 (0.59) HK27 (-1.45) HK28 (0.79) HK29 (-0.59) HK31 (-0.22) HK33 (-0.74) HK36 (0.59) HK37 (0.00) HK38 (3.14) HK39 (-3.08) HK42 (-3.01) HK46 (-0.73) HK47 (-1.38) HK49 (3.27) HK62 (-2.07) HK63 (-0.65) HK64 (-1.82) HK67 (-1.14) HK84 (-1.35) HK85 (2.06) SF1 (0.00) SF12 (-2.24) SF15 (0.21) SF17 (-0.96) SF18 (-0.98) SF21 (-0.45) SF22 (5.30) SF23 (0.04) SF32 (-1.95) SF34 (1.43) SF35 (-1.72) SF3 (0.52) SF30 (-3.65) HK2 (0.45) HK23 (-2.77) HK41 (-0.35) SF4 (-1.08) SF8 (-1.27) SF9 (-2.90)