OncoDB.HCC Expression View

Gene name : CA1
Ensembl ID ENSG00000133742
Description Carbonic anhydrase 1 (EC 4.2.1.1) (Carbonic anhydrase I) (Carbonate dehydratase I) (CA-I). [Source:Uniprot/SWISSPROT;Acc:P00915]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
11 percent with 2 folds change ( 2 up and 3 down in 43 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- RT-PCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     Proteomic Analysis - - Li et al., Proteomics 5:1125 (2005)
down     Proteomic Analysis - - Liang et al., Proteomics 5:2258 (2005)
Links Entrez Gene    
Display nearby genome region Chr 8 from 81427089 bp to 91478495 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 275738 -- IMAGE clone locate on exon ( tblastx )
1029200 -- IMAGE clone locate on exon ( tblastx )
1457341 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (-0.91) HK3 (-0.57) HK4 (0.00) HK5 (0.48) HK7 (1.15) HK9 (0.00) HK11 (-0.29) HK12 (0.46) HK13 (0.02) HK14 (0.20) HK15 (-0.35) HK16 (-0.29) HK18 (-0.19) HK19 (-0.86) HK20 (0.43) HK21 (-1.02) HK22 (0.01) HK24 (0.45) HK27 (0.14) HK28 (-0.45) HK29 (0.38) HK31 (-0.21) HK33 (-0.24) HK36 (0.00) HK37 (-0.37) HK38 (-1.13) HK39 (-0.61) HK42 (-0.59) HK46 (0.09) HK47 (0.53) HK49 (-1.04) HK62 (-0.44) HK63 (0.58) HK64 (0.00) HK67 (0.00) HK84 (0.00) HK85 (1.38) SF1 (-0.13) SF12 (0.00) SF15 (-0.45) SF17 (0.00) SF18 (0.00) SF21 (0.00) SF22 (0.00) SF23 (-0.81) SF32 (0.37) SF34 (-0.09) SF35 (0.00) SF3 (0.00) SF30 (-0.42) HK2 (-0.07) HK23 (0.18) HK41 (-0.56) SF4 (-0.17) SF8 (-0.42) SF9 (-0.55)