OncoDB.HCC Expression View

Gene name : HMGCS2
Ensembl ID ENSG00000134240
Description Hydroxymethylglutaryl-CoA synthase, mitochondrial precursor (EC 2.3.3.10) (HMG-CoA synthase) (3-hydroxy-3-methylglutaryl coenzyme A synthase). [Source:Uniprot/SWISSPROT;Acc:P54868]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
57 percent with 2 folds change ( 21 up and 12 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
down     Proteomic Analysis - - Li et al., Mol Cell Proteomics 3:399 (2004)
down     Proteomic Analysis - - Blanc et al., Proteomics 5:37788 (2005)
Links Entrez Gene    
Display nearby genome region Chr 1 from 115092142 bp to 125113040 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 757222 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.79) HK1 (-0.64) HK3 (-3.36) HK4 (1.27) HK5 (2.94) HK7 (2.17) HK9 (-0.61) HK11 (-0.30) HK12 (-0.77) HK13 (1.33) HK14 (1.23) HK15 (-2.24) HK16 (0.46) HK18 (-0.35) HK19 (1.18) HK20 (-3.02) HK21 (-1.29) HK22 (2.06) HK24 (0.22) HK27 (0.47) HK28 (1.14) HK29 (-0.10) HK31 (0.16) HK33 (0.27) HK36 (1.22) HK37 (-1.90) HK38 (2.62) HK39 (2.51) HK42 (1.22) HK46 (0.92) HK47 (-2.01) HK49 (2.27) HK62 (-0.28) HK63 (0.25) HK64 (-1.76) HK67 (-3.42) HK84 (0.63) HK85 (3.42) SF1 (1.01) SF12 (-0.58) SF15 (-1.19) SF17 (-0.09) SF18 (-0.63) SF21 (0.62) SF22 (4.54) SF23 (0.25) SF32 (1.34) SF34 (3.11) SF35 (0.50) SF3 (0.55) SF30 (4.62) HK2 (-1.29) HK23 (-3.80) HK41 (3.55) SF4 (-0.98) SF8 (-2.10) SF9 (2.95)