OncoDB.HCC Expression View

Gene name : PDGFRA
Ensembl ID ENSG00000134853
Description Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen). [Source:Uniprot/SWISSPROT;Acc:P16234]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
79 percent with 2 folds change ( 0 up and 43 down in 54 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- QPCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene     COSMIC    
Display nearby genome region Chr 4 from 49790204 bp to 59859171 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 52096 -- IMAGE clone locate on exon ( tblastx )
CH2 (-3.35) HK1 (-3.51) HK3 (-0.09) HK4 (0.00) HK5 (-2.75) HK7 (-2.22) HK9 (-3.32) HK11 (0.15) HK12 (-1.07) HK13 (-1.86) HK14 (-2.85) HK15 (-0.67) HK16 (-1.62) HK18 (-3.28) HK19 (-1.07) HK20 (-3.20) HK21 (-0.33) HK22 (-0.90) HK24 (-1.86) HK27 (-1.07) HK28 (-1.71) HK29 (-1.18) HK31 (-2.17) HK33 (-3.89) HK36 (-1.83) HK37 (-2.18) HK38 (-2.36) HK39 (-0.63) HK42 (-3.43) HK46 (-2.51) HK47 (-3.14) HK49 (0.67) HK62 (-1.43) HK63 (-3.88) HK64 (-1.71) HK67 (-2.05) HK84 (-4.32) HK85 (-2.88) SF1 (-2.98) SF12 (-1.67) SF15 (-1.11) SF17 (-2.42) SF18 (0.00) SF21 (0.86) SF22 (-1.48) SF23 (-2.29) SF32 (-2.24) SF34 (0.00) SF35 (0.80) SF3 (-1.60) SF30 (-1.99) HK2 (-2.36) HK23 (-1.28) HK41 (-2.91) SF4 (-0.18) SF8 (-1.09) SF9 (0.63)