OncoDB.HCC Expression View

Gene name : APC
Ensembl ID ENSG00000134982
Description Adenomatous polyposis coli protein (Protein APC). [Source:Uniprot/SWISSPROT;Acc:P25054]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
12 percent with 2 folds change ( 2 up and 5 down in 54 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence methylation     Method -- Methylation    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 5 from 107101483 bp to 117209834 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 429926 -- IMAGE clone locate on exon ( tblastx )
812083 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.27) HK1 (-0.52) HK3 (-0.19) HK4 (-0.62) HK5 (-1.75) HK7 (0.39) HK9 (0.05) HK11 (-0.42) HK12 (-0.10) HK13 (0.13) HK14 (-0.72) HK15 (-0.37) HK16 (-0.38) HK18 (-0.13) HK19 (0.17) HK20 (0.06) HK21 (0.11) HK22 (0.66) HK24 (-0.24) HK27 (-0.42) HK28 (-0.11) HK29 (-0.60) HK31 (0.00) HK33 (0.05) HK36 (-0.12) HK37 (-1.22) HK38 (-0.53) HK39 (-0.03) HK42 (-1.40) HK46 (-0.57) HK47 (-0.53) HK49 (0.14) HK62 (-0.15) HK63 (0.28) HK64 (1.17) HK67 (-0.38) HK84 (0.00) HK85 (-0.57) SF1 (0.54) SF12 (-0.66) SF15 (0.20) SF17 (0.80) SF18 (-1.33) SF21 (-1.12) SF22 (-0.73) SF23 (1.79) SF32 (0.27) SF34 (-0.56) SF35 (0.22) SF3 (0.49) SF30 (0.00) HK2 (0.35) HK23 (0.27) HK41 (-0.00) SF4 (-0.48) SF8 (-0.41) SF9 (-0.72)