OncoDB.HCC Expression View

Gene name : CKAP2
Ensembl ID ENSG00000136108
Description Cytoskeleton-associated protein 2 (Tumor-associated microtubule- associated protein) (CTCL tumor antigen se20-10). [Source:Uniprot/SWISSPROT;Acc:Q8WWK9]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
77 percent with 2 folds change ( 1 up and 37 down in 49 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 13 from 46927596 bp to 56948759 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 71902 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (-4.43) HK3 (-3.23) HK4 (0.00) HK5 (-3.26) HK7 (0.00) HK9 (0.00) HK11 (-2.63) HK12 (-1.50) HK13 (-1.71) HK14 (-2.40) HK15 (-2.45) HK16 (-3.17) HK18 (-1.39) HK19 (-2.03) HK20 (-2.53) HK21 (-0.46) HK22 (0.24) HK24 (-4.15) HK27 (-4.99) HK28 (-1.60) HK29 (-0.55) HK31 (-4.30) HK33 (-3.91) HK36 (-3.37) HK37 (-5.13) HK38 (-0.33) HK39 (-4.23) HK42 (-2.92) HK46 (-2.14) HK47 (-3.00) HK49 (-2.36) HK62 (-0.03) HK63 (-2.40) HK64 (0.00) HK67 (-1.74) HK84 (0.01) HK85 (-1.34) SF1 (-0.97) SF12 (-4.02) SF15 (0.85) SF17 (-3.86) SF18 (-2.70) SF21 (0.00) SF22 (0.00) SF23 (2.22) SF32 (-1.91) SF34 (-2.52) SF35 (0.00) SF3 (-0.08) SF30 (-3.21) HK2 (-1.74) HK23 (-0.82) HK41 (-2.70) SF4 (-3.31) SF8 (-1.44) SF9 (-0.04)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).