OncoDB.HCC Expression View

Gene name : EDNRB
Ensembl ID ENSG00000136160
Description Endothelin B receptor precursor (ET-B) (Endothelin receptor Non- selective type). [Source:Uniprot/SWISSPROT;Acc:P24530]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
64 percent with 2 folds change ( 7 up and 30 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- RT-PCR, Methylation    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     Affy. Microarray - - Iizuka et al., J Cancer Res Clin Oncol 132:473 (2006)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 13 from 72367617 bp to 82391904 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 49665 -- IMAGE clone locate on exon ( tblastx )
271050 -- IMAGE clone locate on exon ( tblastx )
CH2 (-3.82) HK1 (-0.39) HK3 (-0.90) HK4 (-4.84) HK5 (-1.17) HK7 (-1.39) HK9 (-0.84) HK11 (-1.22) HK12 (-2.30) HK13 (-0.36) HK14 (-3.17) HK15 (-1.46) HK16 (-0.12) HK18 (-1.45) HK19 (-1.83) HK20 (-1.07) HK21 (-1.85) HK22 (-0.17) HK24 (-0.29) HK27 (-1.48) HK28 (-3.31) HK29 (-0.50) HK31 (0.38) HK33 (0.12) HK36 (0.18) HK37 (-0.60) HK38 (-0.91) HK39 (-1.13) HK42 (-1.99) HK46 (-1.11) HK47 (-2.78) HK49 (1.41) HK62 (-1.42) HK63 (-0.76) HK64 (-1.72) HK67 (-0.15) HK84 (-3.87) HK85 (-0.24) SF1 (-2.19) SF12 (-1.37) SF15 (-1.98) SF17 (1.36) SF18 (1.46) SF21 (1.73) SF22 (1.20) SF23 (-1.29) SF32 (-0.08) SF34 (0.63) SF35 (-1.74) SF3 (-2.68) SF30 (-2.71) HK2 (1.09) HK23 (-1.41) HK41 (1.42) SF4 (-0.86) SF8 (-0.44) SF9 (-2.02)