OncoDB.HCC Expression View

Gene name : ALDOB
Ensembl ID ENSG00000136872
Description Fructose-bisphosphate aldolase B (EC 4.1.2.13) (Liver-type aldolase). [Source:Uniprot/SWISSPROT;Acc:P05062]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
46 percent with 2 folds change ( 6 up and 20 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- QPCR, Western    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
down     Proteomic Analysis - - Kim et al., Clin Cancer Research 9:5493 (2003)
down     Proteomic Analysis - - Li et al., Mol Cell Proteomics 3:399 (2004)
down     Proteomic Analysis - - Yokoyama et al., Proteomics 4:21111 (2004)
down     Proteomic Analysis - - Li et al., Proteomics 5:1125 (2005)
down     Proteomic Analysis - - Liang et al., Proteomics 5:2258 (2005)
Links Entrez Gene    
Display nearby genome region Chr 9 from 98222681 bp to 108237926 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 121997 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.82) HK1 (-0.56) HK3 (0.00) HK4 (-0.01) HK5 (-1.63) HK7 (-1.27) HK9 (0.86) HK11 (-1.70) HK12 (-1.57) HK13 (1.01) HK14 (-1.10) HK15 (-1.09) HK16 (-0.65) HK18 (-1.38) HK19 (-0.74) HK20 (-1.24) HK21 (-1.66) HK22 (1.59) HK24 (-0.63) HK27 (-2.44) HK28 (1.48) HK29 (-0.55) HK31 (0.46) HK33 (0.23) HK36 (1.46) HK37 (-2.33) HK38 (0.42) HK39 (-0.59) HK42 (-1.74) HK46 (-1.39) HK47 (-1.84) HK49 (1.16) HK62 (-0.55) HK63 (0.10) HK64 (0.16) HK67 (-0.64) HK84 (-1.76) HK85 (-0.45) SF1 (-0.82) SF12 (0.52) SF15 (-0.30) SF17 (1.50) SF18 (-1.37) SF21 (-0.53) SF22 (0.75) SF23 (0.46) SF32 (-0.82) SF34 (-0.31) SF35 (0.00) SF3 (-0.92) SF30 (-0.54) HK2 (-4.42) HK23 (-1.13) HK41 (0.31) SF4 (-0.47) SF8 (-1.67) SF9 (-3.84)